R&D Services

Vaccine Process Development

Our process development services are based on a systematic, stepwise methodology focused on the identification of key process parameters. Our approach is resource efficient, reducing development time and costs, without compromising quality. Our objective is to build functional, scalable and above all, transferable processes. With GMP in mind from the beginning, both USP and DSP are based on both multi-use and single-use processing platforms. Our expertise in working with high demand organisms and familiarity with Viral and Bacterial Vaccines including Vectored Vaccine makes us ideal partners for complex projects. Working with Vaxfarm will help you meet the expectations to develop a process with commercial requirements in mind.

Process development activities include:

• Pathogen based and target based vaccine design
• in silico modelling for epitope identification
• Adaptation of adherent cells to suspension
• Weaning of cultures to serum-free conditions
• RCB and RVB generation
• Optimization of Multiplicity of Infection (MOI), Point of Infection (POI) and Point of Harvest (POH)
• Evaluation/optimization of medium and supplements
• Optimization of virus recovery from bulk harvest
• Fermentation development focusing on disposable systems
• Purification development comprising filtration and chromatographic techniques
• Generation of purified virus reference materials by batch ultra-centrifugation
• Genomic stability studies
• Assay integration/development particularly covering live virus products